Comparison of pregnancy latency in preterm preeclampsia with oral labetalol versus extended-release nifedipine

To compare pregnancy latency achieved with oral labetalol versus extended-release nifedipine during expectant management of preterm preeclampsia severe features (PEC-SF). This is a retrospective cohort study patients initiated on antihypertensive therapy or admission for PEC-SF < 34 weeks between 1/2013 and 4/2022. Those prior to another indication delivery were excluded (monochorionic-monoamniotic twins, higher order multiples, absent reversed umbilical artery Dopplers). Pregnancy (from agent initiation decision) was compared groups. Secondary outcomes included need initial dose uptitration, addition second agent, acute therapy, refractory hypertension. Linear modified Poisson regression models used estimate adjusted mean differences (AMD) 95% confidence intervals. The 78 (Table 1). Comparing those 2), there no difference in (6.2 (7.5) vs 5.4 (7.4) days, AMD 1.1 CI [-2.1, 4.4]), nor the proportion achieving 1 week (25.0% 23.8%, respectively, 2.9%, [-16.5, 22.3]). less likely require (16.7% 38.1% nifedipine, -18.4, [-37.3, 0.5]). There among nifedipine. Patients may be but comparative outcome estimates limited by small size. Further investigations larger should performed evaluate any relative advantages two agents.View Large Image Figure ViewerDownload Hi-res image Download (PPT)